Here, the authors provide a progress report on an evolving research program that uses a robotic system to improve the quality and throughput for laboratory animal studies while reducing the numbers of animals used and enhancing animal comfort. The pre-clinical bioanalytical process with animal models is designed to help researchers better understand specific chemical effects on the human body, including oral absorption kinetics, distribution, metabolism and excretion (ADME); blood–brain barrier penetration; drug–drug interactions and the influences on biomarkers, hematology, electrophysiology and behavior. The majority of animal test samples are processed by liquid chromatography–mass spectrometry (LC–MS) techniques, augmented by robotic sample preparation tools. The authors have implemented a robotic system that can improve both the quality and throughput for laboratory animal studies while reducing the numbers of animals used and enhancing animal comfort. Here, we provide a progress report on this evolving research program in cooperation with multiple pharmaceutical and drug development companies.
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